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FGD4 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q96M96
Clone Names 100405044
Peptide ID 100405044
Additional Information
Gene ID 121512
Other Names FYVE, RhoGEF and PH domain-containing protein 4, Actin filament-binding protein frabin, FGD1-related F-actin-binding protein, Zinc finger FYVE domain-containing protein 6, FGD4, FRABP, ZFYVE6
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGD4
Synonyms FRABP, ZFYVE6
Function Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity).
Cellular Location Cytoplasm, cytoskeleton. Cell projection, filopodium. Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity).
Tissue Location Expressed in different tissues, including brain, cerebellum, peripheral nerve, skeletal muscle, heart, uterus, placenta and testis.
Research Areas
Citations (0)

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This gene encodes a protein that is involved in theregulation of the actin cytoskeleton and cell shape. This proteincontains an actin filament-binding domain, which together with itsDbl homology domain and one of its pleckstrin homology domains, canform microspikes. This protein can activate MAPK8 independently ofthe actin filament-binding domain, and it is also involved in theactivation of CDC42 via the exchange of bound GDP for free GTP. Theactivation of CDC42 also enables this protein to play a role inmediating the cellular invasion of Cryptosporidium parvum, anintracellular parasite that infects the gastrointestinal tract.Mutations in this gene can cause Charcot-Marie-Tooth disease type4H (CMT4H), a disorder of the peripheral nervous system. [providedby RefSeq].


Rose, J. Phd, et al. Mol. Med. (2010) In press :Fabrizi, G.M., et al. Neurology 72(13):1160-1164(2009)Houlden, H., et al. Neurology 72(7):617-620(2009)Horlock, C., et al. Int. Arch. Allergy Immunol. 150(3):237-251(2009)Stendel, C., et al. Am. J. Hum. Genet. 81(1):158-164(2007)

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Cat# BP12983a
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