FGD4 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96M96 |
---|---|
Clone Names | 100405044 |
Gene ID | 121512 |
---|---|
Other Names | FYVE, RhoGEF and PH domain-containing protein 4, Actin filament-binding protein frabin, FGD1-related F-actin-binding protein, Zinc finger FYVE domain-containing protein 6, FGD4, FRABP, ZFYVE6 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | FGD4 |
---|---|
Synonyms | FRABP, ZFYVE6 |
Function | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). |
Cellular Location | Cytoplasm, cytoskeleton. Cell projection, filopodium. Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). |
Tissue Location | Expressed in different tissues, including brain, cerebellum, peripheral nerve, skeletal muscle, heart, uterus, placenta and testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is involved in theregulation of the actin cytoskeleton and cell shape. This proteincontains an actin filament-binding domain, which together with itsDbl homology domain and one of its pleckstrin homology domains, canform microspikes. This protein can activate MAPK8 independently ofthe actin filament-binding domain, and it is also involved in theactivation of CDC42 via the exchange of bound GDP for free GTP. Theactivation of CDC42 also enables this protein to play a role inmediating the cellular invasion of Cryptosporidium parvum, anintracellular parasite that infects the gastrointestinal tract.Mutations in this gene can cause Charcot-Marie-Tooth disease type4H (CMT4H), a disorder of the peripheral nervous system. [providedby RefSeq].
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Fabrizi, G.M., et al. Neurology 72(13):1160-1164(2009)Houlden, H., et al. Neurology 72(7):617-620(2009)Horlock, C., et al. Int. Arch. Allergy Immunol. 150(3):237-251(2009)Stendel, C., et al. Am. J. Hum. Genet. 81(1):158-164(2007)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.