|Other Names||Cation channel sperm-associated protein 1, CatSper1, hCatSper, CATSPER1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.|
|Cellular Location||Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Calcium ions play a primary role in the regulation ofsperm motility. This gene belongs to a family of putative cationchannels that are specific to spermatozoa and localize to theflagellum. The protein family features a single repeat with sixmembrane-spanning segments and a predicted calcium-selective poreregion.
Li, H., et al. Fertil. Steril. 92(3):1141-1146(2009)Avenarius, M.R., et al. Am. J. Hum. Genet. 84(4):505-510(2009)Zhang, D., et al. J. Biol. Chem. 281(31):22332-22341(2006)Li, H.G., et al. Asian J. Androl. 8(3):301-306(2006)Clapham, D.E., et al. Pharmacol. Rev. 57(4):451-454(2005)
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