LZTS1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y250 |
---|---|
Clone Names | 110111050 |
Gene ID | 11178 |
---|---|
Other Names | Leucine zipper putative tumor suppressor 1, F37/esophageal cancer-related gene-coding leucine-zipper motif, Fez1, LZTS1, FEZ1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | LZTS1 |
---|---|
Synonyms | FEZ1 |
Function | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. |
Cellular Location | Cytoplasm. Cell membrane. Cell projection, dendritic spine Postsynaptic density. Synapse Note=Associated with the plasma membrane and with microtubules Detected in dendritic spines, especially in the postsynaptic density (By similarity). |
Tissue Location | Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas Not detectable in primary tumors from breast and prostate and in many cancer cell lines. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a tumor suppressor protein that isubiquitously expressed in normal tissues. In uveal melanomas,expression of this protein is silenced in rapidly metastasizing andmetastatic tumor cells but has normal expression in slowlymetastasizing or nonmetastasizing tumor cells. This protein mayhave a role in cell-cycle control by interacting with theCdk1/cyclinB1 complex. This gene is located on chromosomal region8p22. Loss of heterozygosity (LOH) in the 8p arm is a commoncharacteristic of many types of cancer.
References
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Chattopadhyay, I., et al. Mutat. Res. 696(2):130-138(2010)Califano, D., et al. J. Cell. Physiol. 222(2):382-386(2010)Shyn, S.I., et al. Mol. Psychiatry (2009) In press :Canova, C., et al. Cancer Res. 69(7):2956-2965(2009)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.