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UNC5D Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6UXZ4
Clone Names 110111065
Additional Information
Gene ID 137970
Other Names Netrin receptor UNC5D, Protein unc-5 homolog 4, Protein unc-5 homolog D, UNC5D, KIAA1777, UNC5H4
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UNC5D
Synonyms KIAA1777, UNC5H4 {ECO:0000303|Ref.2}
Function Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Research Areas
Citations (0)
citation

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Background

UNC5D is receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Wang, H., et al. Biochem. Biophys. Res. Commun. 370(4):594-598(2008)Choy, K.W., et al. Physiol. Genomics 25(1):9-15(2006)Zhong, Y., et al. Cereb. Cortex 14(10):1144-1152(2004)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)

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$ 277.78
Cat# BP13072c
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