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C7orf60 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q1RMZ1 |
|---|---|
| Clone Names | 91230164 |
| Gene ID | 154743 |
|---|---|
| Other Names | Probable methyltransferase BTM2 homolog {ECO:0000255|HAMAP-Rule:MF_03044}, 211- {ECO:0000255|HAMAP-Rule:MF_03044}, C7orf60 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13097b was selected from the C-term region of C7orf60. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BMT2 {ECO:0000255|HAMAP-Rule:MF_03044, ECO:0000312|HGNC:HGNC:26475} |
|---|---|
| Function | S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071, PubMed:35776786). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071, PubMed:35776786). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071, PubMed:35776786). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of this protein remains unknown.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Anney, R.J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1369-1378 (2008) :
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