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C7orf60 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q1RMZ1
Clone Names 91230164
Peptide ID 91230164
Additional Information
Gene ID 154743
Other Names Probable methyltransferase BTM2 homolog {ECO:0000255|HAMAP-Rule:MF_03044}, 211- {ECO:0000255|HAMAP-Rule:MF_03044}, C7orf60
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13097b was selected from the C-term region of C7orf60. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SAMTR
Function S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071). Acts as a sensor of S- adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential).
Research Areas
Citations (0)

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Background

The specific function of this protein remains unknown.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :Anney, R.J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1369-1378 (2008) :

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Cat# BP13097b
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