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SEC63 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UGP8
Clone Names 100324128
Peptide ID 100324128
Additional Information
Gene ID 11231
Other Names Translocation protein SEC63 homolog, SEC63, SEC63L
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13128a was selected from the N-term region of SEC63. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEC63 {ECO:0000303|PubMed:28375157, ECO:0000312|HGNC:HGNC:21082}
Function Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Widely expressed, with high levels in the liver.
Research Areas
Citations (0)

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Background

The Sec61 complex is the central component of the proteintranslocation apparatus of the endoplasmic reticulum (ER) membrane.The protein encoded by this gene and SEC62 protein are found to beassociated with ribosome-free SEC61 complex. It is speculated thatSec61-Sec62-Sec63 may perform post-translational proteintranslocation into the ER. The Sec61-Sec62-Sec63 complex might alsoperform the backward transport of ER proteins that are subject tothe ubiquitin-proteasome-dependent degradation pathway. The encodedprotein is an integral membrane protein located in the rough ER.

References

Waanders, E., et al. Clin. Genet. 78(1):47-56(2010)van Keimpema, L., et al. Liver Int. (2010) In press :Waanders, E., et al. Histochem. Cell Biol. 129(3):301-310(2008)You, K.T., et al. PLoS Biol. 5 (5), E109 (2007) :Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

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Cat# BP13128a
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