Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
SEC63 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UGP8 |
|---|---|
| Clone Names | 100324128 |
| Gene ID | 11231 |
|---|---|
| Other Names | Translocation protein SEC63 homolog, SEC63, SEC63L |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13128a was selected from the N-term region of SEC63. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SEC63 {ECO:0000303|PubMed:28375157, ECO:0000312|HGNC:HGNC:21082} |
|---|---|
| Function | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin- 1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed, with high levels in the liver. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The Sec61 complex is the central component of the proteintranslocation apparatus of the endoplasmic reticulum (ER) membrane.The protein encoded by this gene and SEC62 protein are found to beassociated with ribosome-free SEC61 complex. It is speculated thatSec61-Sec62-Sec63 may perform post-translational proteintranslocation into the ER. The Sec61-Sec62-Sec63 complex might alsoperform the backward transport of ER proteins that are subject tothe ubiquitin-proteasome-dependent degradation pathway. The encodedprotein is an integral membrane protein located in the rough ER.
References
Waanders, E., et al. Clin. Genet. 78(1):47-56(2010)van Keimpema, L., et al. Liver Int. (2010) In press :Waanders, E., et al. Histochem. Cell Biol. 129(3):301-310(2008)You, K.T., et al. PLoS Biol. 5 (5), E109 (2007) :Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
