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CD320 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9NPF0
Clone Names 100405029
Peptide ID 100405029
Additional Information
Gene ID 51293
Other Names CD320 antigen, 8D6 antigen, FDC-signaling molecule 8D6, FDC-SM-8D6, Transcobalamin receptor, TCblR, CD320, CD320, 8D6A
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13137b was selected from the C-term region of CD320. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD320
Synonyms 8D6A
Function Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470). Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631). CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631).
Cellular Location Cell membrane; Single- pass type I membrane protein
Tissue Location Detected in the germinal center (GC) of lymphoid follicles (at protein level) (PubMed:11418631). Expressed abundantly on follicular dendritic cells (FDCs) (PubMed:10727470)
Research Areas
Citations (0)

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The CD320 antigen gene encodes the transcobalamin receptor(TCBLR). Cellular uptake of cobalamin (vitamin B12) is mediated byreceptors expressed on the cell surface. Transcobalamin II (TCN2;MIM 613441), a plasma protein secreted by endothelial cells, bindsthe cobalamin absorbed in the distal ileum and carries 10 to 30% oftotal circulating cobalamin. CD320 encodes a transcobalaminreceptor that binds TCN2-cobalamin at the plasma membrane andinternalizes the complex by endocytosis (Quadros et al., 2009[PubMed 18779389]).


Jiang, W., et al. Gene 466 (1-2), 49-55 (2010) :Pangilinan, F., et al. J. Med. Genet. 47(10):677-685(2010)Quadros, E.V., et al. Hum. Mutat. 31(8):924-929(2010)Quadros, E.V., et al. Blood 113(1):186-192(2009)Cho, W., et al. BMB Rep 41(12):863-867(2008)

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Cat# BP13137b
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