|Other Names||Prolactin-releasing peptide, PrRP, Prolactin-releasing hormone, Prolactin-releasing peptide PrRP31, Prolactin-releasing peptide PrRP20, PRLH, PRH|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13150c was selected from the Center region of PRLH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.|
|Tissue Location||Medulla oblongata and hypothalamus. EMBL; AB015419; BAA29027.1; -; mRNA EMBL; BC069081; AAH69081.1; -; mRNA EMBL; BC069284; AAH69284.1; -; mRNA CCDS; CCDS2519.1; - RefSeq; NP_056977.1; NM_015893.1 UniGene; Hs.247710; - ProteinModelPortal; P81277; - STRING; 9606.ENSP00000165524; - iPTMnet; P81277; - PhosphoSitePlus; P81277; - BioMuta; PRLH; - DMDM; 8134649; - PaxDb; P81277; - PRIDE; P81277; - ProteomicsDB; 57694; - Ensembl; ENST00000165524; ENSP00000165524; ENSG00000071677 GeneID; 51052; - KEGG; hsa:51052; - CTD; 51052; - DisGeNET; 51052; - EuPathDB; HostDB:ENSG00000071677.1; - GeneCards; PRLH; - HGNC; HGNC:17945; PRLH HPA; HPA014976; - MIM; 602663; gene neXtProt; NX_P81277; - OpenTargets; ENSG00000071677; - PharmGKB; PA134927756; - eggNOG; ENOG410J49T; Eukaryota eggNOG; ENOG4111800; LUCA GeneTree; ENSGT00390000005489; - HOGENOM; HOG000115720; - HOVERGEN; HBG004601; - InParanoid; P81277; - KO; K05269; - OMA; RAHQHSM; - OrthoDB; 1486353at2759; - PhylomeDB; P81277; - TreeFam; TF330717; - Reactome; R-HSA-375276; Peptide ligand-binding receptors GeneWiki; PRLH; - GeneWiki; Prolactin-releasing_peptide; - GenomeRNAi; 51052; - PRO; PR:P81277; - Proteomes; UP000005640; Chromosome 2 Bgee; ENSG00000071677; Expressed in 90 organ(s), highest expression level in C1 segment of cervical spinal cord ExpressionAtlas; P81277; baseline and differential Genevisible; P81277; HS GO; GO:0005737; C:cytoplasm; IEA:Ensembl GO; GO:0005576; C:extracellular region; TAS:Reactome GO; GO:0005179; F:hormone activity; TAS:ProtInc GO; GO:0005184; F:neuropeptide hormone activity; IEA:Ensembl GO; GO:0031861; F:prolactin-releasing peptide receptor binding; IEA:Ensembl GO; GO:0048483; P:autonomic nervous system development; IEA:Ensembl GO; GO:0006112; P:energy reserve metabolic process; IEA:Ensembl GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:Ensembl GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl GO; GO:0002023; P:reduction of food intake in response to dietary excess; IEA:Ensembl GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl GO; GO:0009749; P:response to glucose; IEA:Ensembl GO; GO:0032868; P:response to insulin; IEA:Ensembl GO; GO:0001894; P:tissue homeostasis; IEA:Ensembl InterPro; IPR026194; PrRP PANTHER; PTHR17206; PTHR17206; 1 Pfam; PF15172; Prolactin_RP; 1 2: Evidence at transcript level; Amidation; Cleavage on pair of basic residues; Complete proteome; Hormone; Reference proteome; Secreted; Signal SIGNAL 1 22 PEPTIDE 23 53 Prolactin-releasing peptide PrRP31 /FTId=PRO_0000022144 PEPTIDE 34 53 Prolactin-releasing peptide PrRP20 /FTId=PRO_0000022145 PROPEP 58 87 /FTId=PRO_0000022146 MOD_RES 53 53 Phenylalanine amide. SEQUENCE 87 AA; 9639 MW; 229A2F3F50CF981B CRC64; MKVLRAWLLC LLMLGLALRG AASRTHRHSM EIRTPDINPA WYASRGIRPV GRFGRRRATL GDVPKPGLRP RLTCFPLEGG AMSSQDG|
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Provided below are standard protocols that you may find useful for product applications.
Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.
Lagerstrom, M.C., et al. Ann. N. Y. Acad. Sci. 1040, 368-370 (2005) :Takahashi, K., et al. Peptides 23(6):1135-1140(2002)Yasui, Y., et al. Endocr. J. 48(3):397-401(2001)Langmead, C.J., et al. Br. J. Pharmacol. 131(4):683-688(2000)Zhang, X., et al. J. Clin. Endocrinol. Metab. 84(12):4652-4655(1999)
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