|Other Names||Acidic fibroblast growth factor intracellular-binding protein, aFGF intracellular-binding protein, FGF-1 intracellular-binding protein, FIBP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13232c was selected from the Center region of FIBP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).|
|Cellular Location||Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmic membranes, particularly of mitochondria|
|Tissue Location||Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
Acidic fibroblast growth factor is mitogenic for a varietyof different cell types and acts by stimulating mitogenesis orinducing morphological changes and differentiation. The FIBPprotein is an intracellular protein that binds selectively toacidic fibroblast growth factor (aFGF). It is postulated that FIBPmay be involved in the mitogenic action of aFGF. Two transcriptvariants encoding different isoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Giatromanolaki, A., et al. Mediators Inflamm. 2007, 67187 (2007) :Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Skjerpen, C.S., et al. EMBO J. 21(15):4058-4069(2002)
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