|Other Names||Transcription factor AP-2-beta, AP2-beta, Activating enhancer-binding protein 2-beta, TFAP2B|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13256b was selected from the C-term region of TFAP2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the AP-2 family oftranscription factors. AP-2 proteins form homo- or hetero-dimerswith other AP-2 family members and bind specific DNA sequences.They are thought to stimulate cell proliferation and suppressterminal differentiation of specific cell types during embryonicdevelopment. Specific AP-2 family members differ in theirexpression patterns and binding affinity for different promoters.This protein functions as both a transcriptional activator andrepressor. Mutations in this gene result in autosomal dominant Charsyndrome, suggesting that this gene functions in thedifferentiation of neural crest cell derivatives. [provided byRefSeq].
Li, X., et al. Genes Chromosomes Cancer 49(9):819-830(2010)Hotta, K., et al. J. Hum. Genet. (2010) In press :Ugi, S., et al. Obesity (Silver Spring) 18(7):1277-1282(2010)Nordquist, N., et al. Brain Res. 1305 SUPPL, S20-S26 (2009) :Lindgren, C.M., et al. PLoS Genet. 5 (6), E1000508 (2009) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.