|Other Names||Humanin, Humanin mitochondrial, HNM, MT-RNR2 (HGNC:7471)|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1325a was selected from the region of human Humanin. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role as a neuroprotective factor. Protects against death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2. Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP.|
|Cellular Location||Secreted. Cytoplasm|
|Tissue Location||Expressed in the heart, skeletal muscles, kidney and liver. Lesser but significant expression is observed in the brain and the gastrointestinal tract. Expressed in the AD brain, where it is found in some of the large intact neurons of the occipital lobes and small and round reactive glial cells in the hippocampus.|
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Humanin is a secreted protein that serves as a neuroprotective factor against death induced by an array of Alzheimer's related proteins, including beta amyloid. Humanin diminishes aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and competitively inhibits the access of FPRL1 to APP. This protein has also been demonstrated to block the translocation of BAX from cytosol to mitochondria. Expression of humanin is abundant in the heart, skeletal muscles, kidney and liver. Lesser but significant expression is observed in the brain and the gastrointestinal tract. Humanin is well-expressed in brain tissue afflicted with Alzheimer's, where it is found in some of the large intact neurons of the occipital lobes and small and round reactive glial cells in the hippocampus. Intracellular levels of human are regulated by TRIM11 through the proteasomal pathway.
Proc. Natl. Acad. Sci. U.S.A. 98 (11), 6336-6341 (2001) Neurosci. Lett. 324 (3), 227-231 (2002) Proc. Natl. Acad. Sci. U.S.A. 100:13042-13047(2003). J. Neurosci. 21:9235-9245(2001). Nature 423:456-461(2003). Eur. J. Neurosci. 17:1150-1158(2003). J. Immunol. 172:7078-7085(2004).
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