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TRIM13 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O60858
Clone Names 100408307
Peptide ID 100408307
Additional Information
Gene ID 10206
Other Names E3 ubiquitin-protein ligase TRIM13, 632-, B-cell chronic lymphocytic leukemia tumor suppressor Leu5, Leukemia-associated protein 5, Putative tumor suppressor RFP2, RING finger protein 77, Ret finger protein 2, Tripartite motif-containing protein 13, TRIM13, LEU5, RFP2, RNF77
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13285a was selected from the N-term region of TRIM13. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM13
Synonyms LEU5, RFP2, RNF77
Function Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor (PubMed:22178386). Plays also a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation (PubMed:28087809). Participates as well in T-cell receptor- mediated NF-kappa-B activation (PubMed:25088585). In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B (PubMed:25152375).
Cellular Location Endoplasmic reticulum membrane; Single- pass membrane protein Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum
Research Areas
Citations (0)

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This gene encodes a member of the tripartite motif (TRIM)family. The TRIM motif includes three zinc-binding domains, a RING,a B-box type 1 and a B-box type 2, and a coiled-coil region. Thisgene is located on chromosome 13 within the minimal deletion regionfor B-cell chronic lymphocytic leukemia. Multiple alternativelyspliced transcript variants have been found for this gene.


Lerner, M., et al. Mol. Biol. Cell 18(5):1670-1682(2007)Skoblov, M., et al. Biochem. Biophys. Res. Commun. 342(3):859-866(2006)Corcoran, M.M., et al. Genes Chromosomes Cancer 40(4):285-297(2004)Dunham, A., et al. Nature 428(6982):522-528(2004)van Everdink, W.J., et al. Cancer Genet. Cytogenet. 146(1):48-57(2003)

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Cat# BP13285a
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