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TRIM3 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O75382
Clone Names 100408316
Peptide ID 100408316
Additional Information
Gene ID 10612
Other Names Tripartite motif-containing protein 3, Brain-expressed RING finger protein, RING finger protein 22, RING finger protein 97, TRIM3, BERP, RNF22, RNF97
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13286a was selected from the N-term region of TRIM3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM3
Synonyms BERP, RNF22, RNF97
Function Probably involved in vesicular trafficking via its association with the CART complex (PubMed:15772161). The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity).
Cellular Location Cytoplasm. Early endosome. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9R1R2}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9R1R2}
Tissue Location Expressed in brain, heart, uterus and testis.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of thetripartite motif (TRIM) family, also called the'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins.The TRIM motif includes three zinc-binding domains, a RING, a B-boxtype 1 and a B-box type 2, and a coiled-coil region. This proteinlocalizes to cytoplasmic filaments. It is similar to a rat proteinwhich is a specific partner for the tail domain of myosin V, aclass of myosins which are involved in the targeted transport oforganelles. The rat protein can also interact with alpha-actinin-4.Thus it is suggested that this human protein may play a role inmyosin V-mediated cargo transport. Alternatively spliced transcriptvariants encoding the same isoform have been identified. [providedby RefSeq].


Cheung, C.C., et al. Proc. Natl. Acad. Sci. U.S.A. 107(26):11883-11888(2010)Azuma, K., et al. Endocr. J. 57(5):455-462(2010)Mosesson, Y., et al. Dev. Cell 16(5):687-698(2009)Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)Boulay, J.L., et al. BMC Cancer 9, 71 (2009) :

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Cat# BP13286a
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