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RAB21 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9UL25
Clone Names 100324270
Peptide ID 100324270
Additional Information
Gene ID 23011
Other Names Ras-related protein Rab-21, RAB21, KIAA0118
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13377b was selected from the C-term region of RAB21. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB21
Synonyms KIAA0118
Function Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148).
Cellular Location Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network Golgi apparatus membrane. Early endosome membrane Cytoplasmic vesicle membrane Cleavage furrow. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity). In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961). During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435). In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435) {ECO:0000250|UniProtKB:P35282, ECO:0000269|PubMed:10887961, ECO:0000269|PubMed:18804435}
Tissue Location Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression
Research Areas
Citations (0)

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RAB21 belongs to the RAB family of small GTP-bindingproteins that regulate intracellular vesicle targeting (Opdam etal., 2000 [PubMed 10887961]).


Burgo, A., et al. EMBO Rep. 10(10):1117-1124(2009)Pellinen, T., et al. Dev. Cell 15(3):371-385(2008)Delprato, A., et al. Nat. Struct. Mol. Biol. 14(5):406-412(2007)Pellinen, T., et al. J. Cell Biol. 173(5):767-780(2006)Eathiraj, S., et al. Nature 436(7049):415-419(2005)

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Cat# BP13377b
Availability: Back Order
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