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CACNA2D2 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9NY47
Clone Names 101008169
Peptide ID 101008169
Additional Information
Gene ID 9254
Other Names Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2, Voltage-dependent calcium channel subunit alpha-2-2, Voltage-dependent calcium channel subunit delta-2, CACNA2D2, KIAA0558
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13380c was selected from the Center region of CACNA2D2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0558
Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein. Note=Colocalizes with CACNA1A in lipid raft fractions.
Tissue Location Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.
Research Areas
Citations (0)

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This gene encodes a member of the alpha-2/delta subunitfamily, a protein in the voltage-dependent calcium channel complex.Calcium channels mediate the influx of calcium ions into the cellupon membrane polarization and consist of a complex of alpha-1,alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Variousversions of each of these subunits exist, either expressed fromsimilar genes or the result of alternative splicing. Research on ahighly similar protein in rabbit suggests the protein described inthis record is cleaved into alpha-2 and delta subunits. Alternatetranscriptional splice variants of this gene, encoding differentisoforms, have been characterized.


Donato, R., et al. J. Neurosci. 26(48):12576-12586(2006)Ivanov, S.V., et al. Am. J. Pathol. 165(3):1007-1018(2004)Carboni, G.L., et al. Oncogene 22(4):615-626(2003)Honorio, S., et al. Mol. Cell. Probes 15(6):391-393(2001)Angeloni, D., et al. Mol. Cell. Probes 15(2):125-127(2001)

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Cat# BP13380c
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