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GABRB1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P18505 |
|---|
| Gene ID | 2560 |
|---|---|
| Other Names | Gamma-aminobutyric acid receptor subunit beta-1, GABA(A) receptor subunit beta-1, GABRB1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GABRB1 (HGNC:4081) |
|---|---|
| Function | Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217, PubMed:26950270). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain one or two GABA active binding sites located at the alpha and beta subunit interfaces, depending on subunit composition (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10449790, PubMed:16412217, PubMed:26950270). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:16412217, PubMed:26950270). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity). |
| Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:P08220}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08220}. Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08220} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor.
References
Craddock, N., et al. Mol. Psychiatry 15(2):146-153(2010)Hamshere, M.L., et al. Br J Psychiatry 195(1):23-29(2009)Tabakoff, B., et al. BMC Biol. 7, 70 (2009)
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