TREX2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BQ50 |
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Clone Names | 90713223 |
Gene ID | 11219 |
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Other Names | Three prime repair exonuclease 2, 3'-5' exonuclease TREX2, TREX2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8558b was selected from the C-term region of human TREX2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TREX2 |
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Function | Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair. |
Cellular Location | Nucleus. |
Tissue Location | Detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon, small intestine, stomach and thymus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TREX2 is a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.
References
Hur,J.W., et.al., Rheumatol. Int. 28 (8), 783-789 (2008)Chen,M.J., et.al., Nucleic Acids Res. 35 (8), 2682-2694 (2007)
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