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LTC4S Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q16873 |
|---|---|
| Clone Names | 90723214 |
| Gene ID | 4056 |
|---|---|
| Other Names | Leukotriene C4 synthase, LTC4 synthase, Leukotriene-C(4) synthase, LTC4S |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8584a was selected from the N-term region of human LTC4S. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LTC4S |
|---|---|
| Function | Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:7937884, PubMed:27791009, PubMed:27365393, PubMed:9153254, PubMed:23409838). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009). |
| Cellular Location | Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein |
| Tissue Location | Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets |
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Provided below are standard protocols that you may find useful for product applications.
Background
LTC4S catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
References
Song,X.Y., et.al., Diabetologia 52 (8), 1543-1553 (2009)Schurks,M., et.al., J Pain 10 (7), 759-766 (2009)
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