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MPZ Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P25189 |
|---|---|
| Clone Names | 90415110 |
| Gene ID | 4359 |
|---|---|
| Other Names | Myelin protein P0, Myelin peripheral protein, MPP, Myelin protein zero, MPZ |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8621b was selected from the C-term region of human MPZ. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MPZ |
|---|---|
| Function | Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Found only in peripheral nervous system Schwann cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
MPZ is a major structural protein of peripheral myelin. Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
References
Tachi,N., et.al., Brain Dev. 6 (6), 560-565 (1984)Hayasaka,K.,et.al., Biochem. Biophys. Res. Commun. 180 (2), 515-518 (1991)Hayasaka,K., et.al., Genomics 17 (3), 755-758 (1993)
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