KMO Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O15229 |
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Clone Names | 90504090 |
Gene ID | 8564 |
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Other Names | Kynurenine 3-monooxygenase {ECO:0000255|HAMAP-Rule:MF_03018}, 114139 {ECO:0000255|HAMAP-Rule:MF_03018}, Kynurenine 3-hydroxylase {ECO:0000255|HAMAP-Rule:MF_03018}, KMO |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8660c was selected from the Center region of human KMO. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | KMO {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000312|HGNC:HGNC:6381} |
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Function | Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable). |
Cellular Location | Mitochondrion outer membrane {ECO:0000255|HAMAP- Rule:MF_03018, ECO:0000269|PubMed:9237672}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672} |
Tissue Location | Highest levels in placenta and liver. Detectable in kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Kynurenine 3-monooxygenase (KMO; EC 1.14.13.9) is an NADPH-dependent flavin monooxygenase that catalyzes the hydroxylation of the L-tryptophan metabolite L-kynurenine to form L-3-hydroxykynurenine.
References
Ligam,P., et.al., Placenta 26 (6), 498-504 (2005)
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