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MAP6 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96JE9
Clone Names 90625117
Additional Information
Gene ID 4135
Other Names Microtubule-associated protein 6, MAP-6, Stable tubule-only polypeptide, STOP, MAP6, KIAA1878
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8670c was selected from the Center region of human MAP6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP6
Synonyms KIAA1878
Function Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A- mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity).
Cellular Location Cytoplasm, cytoskeleton. Golgi apparatus {ECO:0000250|UniProtKB:Q63560}. Cell projection, axon {ECO:0000250|UniProtKB:Q63560}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63560}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q63560}; Lipid-anchor {ECO:0000250|UniProtKB:Q63560}; Cytoplasmic side {ECO:0000250|UniProtKB:Q63560}. Note=Localizes predominantly in the proximal part of the axon (By similarity). Preferentially is concentrated on a portion of the microtubule polymer in which tubulin is modified by detyrosination and acetylation and is also resistant to depolymerization induced by both nocodazole and cold (By similarity) In unpolarized neurons, localizes to the Golgi and to secretory vesicles accumulating transiently at the tips of a subset of neurites (By similarity). Following neuronal polarization and during axon outgrowth, accumulates in the axonal growth cone and subsequently localizes throughout the axon (By similarity). Partially localizes to dendrites in mature neurons (By similarity). Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS) (PubMed:14692697) {ECO:0000250|UniProtKB:Q63560, ECO:0000269|PubMed:14692697}
Tissue Location Expressed in brain (at protein level). Expressed in spinal cord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study).
Research Areas
Citations (0)

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MAP6 is a microtubule-associated protein. This protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization.


Andrieux,A.,, Genes Dev. 16 (18), 2350-2364 (2002)Bosc,C.,, Biochemistry 42 (42), 12125-12132 (2003)

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$ 277.78
Cat# BP8670c
Availability: 2 weeks
Bulk Size

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