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DRD4 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P21917
Clone Names 90723038
Additional Information
Gene ID 1815
Other Names D(4) dopamine receptor, D(2C) dopamine receptor, Dopamine D4 receptor, DRD4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8760c was selected from the Center region of human DRD4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DRD4
Function Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Highly expressed in retina. Detected at much lower levels in brain, in amygdala, thalamus, hypothalamus, cerebellum and pituitary.
Research Areas
Citations (0)

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Background

DRD4 is the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease.

References

Livingstone,C.D., et.al., Biochem. J. 287 (PT 1), 277-282 (1992)

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$ 277.78
Cat# BP8760c
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Availability: 2 weeks
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