|Other Names||Cdc42 effector protein 3, Binder of Rho GTPases 2, MSE55-related Cdc42-binding protein, CDC42EP3, BORG2, CEP3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8775a was selected from the N-term region of human CDC42EP3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.|
|Cellular Location||Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton|
|Tissue Location||Highly expressed in the heart and weakly in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
CDC42EP3 is probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. It induces pseudopodia formation in fibroblasts.
Simpson,J.C., et.al., EMBO Rep. 1 (3), 287-292 (2000)
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