SOCS1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O15524 |
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Clone Names | 80612054 |
Gene ID | 8651 |
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Other Names | Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, JAB, STAT-induced STAT inhibitor 1, SSI-1, Tec-interacting protein 3, TIP-3, SOCS1, SSI1, TIP3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8790a was selected from the N-term region of human SOCS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SOCS1 |
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Synonyms | SSI1, TIP3 {ECO:0000303|PubMed:9341160} |
Function | Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:32499645, PubMed:33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed:9341160). Regulates IFN-gamma (IFNG)- mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11278610, PubMed:11313480). |
Cellular Location | Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3 |
Tissue Location | Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling(SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.
References
Starr,R.,et.al., Nature 387 (6636), 917-921 (1997)Minamoto,S., et.al., Biochem. Biophys. Res. Commun. 237 (1), 79-83 (1997)
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