AMELX Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q99217 |
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Clone Names | 90121066 |
Gene ID | 265 |
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Other Names | Amelogenin, X isoform, AMELX, AMG, AMGX |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8864b was selected from the C-term region of human AMELX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AMELX |
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Synonyms | AMG, AMGX |
Function | Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. |
Cellular Location | Secreted, extracellular space, extracellular matrix |
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Provided below are standard protocols that you may find useful for product applications.
Background
Amelx (amelogenin X chromosome) is an extracellular matrix protein secreted by ameloblasts and is a major component of enamel matrix. The Amelogenin plays a role in the biomineralization of teeth. It seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. The protein is also thought to play a major role in the structural organization and mineralization of developing enamel. Recently, in addition to their role in enamel formation, the biological activity of enamel proteins in the process of cell differentiation has recently become widely appreciated.
References
Tarasevich,B.J.,et.al., Biopolymers 91 (2), 103-107 (2009)
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