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MGST2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q99735
Clone Names 80311172
Additional Information
Gene ID 4258
Other Names Microsomal glutathione S-transferase 2, Microsomal GST-2, Microsomal GST-II, MGST2, GST2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8876a was selected from the N-term region of human MGST2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MGST2
Synonyms GST2
Function Catalyzes several different glutathione-dependent reactions (PubMed:8703034, PubMed:9278457, PubMed:23409838, PubMed:26656251, PubMed:26066610). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed:9278457, PubMed:23409838). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed:23409838, PubMed:8703034). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed:23409838, PubMed:26656251). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi- pass membrane protein
Tissue Location Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow (PubMed:8703034) Abundantly expressed in human umbilical vein endothelial cells (at protein level) (PubMed:11322876).
Research Areas
Citations (0)

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The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. MGST2 is a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4.


Jakobsson,P.J.,, Am. J. Respir. Crit. Care Med. 161 (2 PT 2), S20-S24 (2000)Sjostrom,M.,, Eur. J. Biochem. 268 (9), 2578-2586 (2001)

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$ 277.78
Cat# BP8876a
Availability: 2 weeks
Bulk Size

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