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MAEL Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96JY0 |
|---|---|
| Clone Names | 90723217 |
| Gene ID | 84944 |
|---|---|
| Other Names | Protein maelstrom homolog, MAEL |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8889b was selected from the C-term region of human MAEL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MAEL |
|---|---|
| Function | Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8BVN9}. Nucleus {ECO:0000250|UniProtKB:Q8BVN9}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity). {ECO:0000250|UniProtKB:Q8BVN9} |
| Tissue Location | Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter {ECO:0000269|PubMed:19693694, ECO:0000269|Ref.1} |
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Provided below are standard protocols that you may find useful for product applications.
Background
MAEL plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage (By similarity).
References
Ehret,G.B., et.al., Eur. J. Hum. Genet. 17 (12), 1650-1657 (2009)Xiao,L., et.al., Mol. Biol. Rep. (2009)
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