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ZYG11B Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9C0D3
Clone Names 90625274
Additional Information
Gene ID 79699
Other Names Protein zyg-11 homolog B, ZYG11B, KIAA1730
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8891b was selected from the C-term region of human ZYG11B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZYG11B (HGNC:25820)
Synonyms KIAA1730
Function Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation (PubMed:31273098).
Research Areas
Citations (0)

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Background

ZYG11B probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.

References

Vasudevan,S., et.al., EMBO Rep. 8 (3), 279-286 (2007)

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$ 277.78
Cat# BP8891b
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Availability: 2 weeks
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