DNASE2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O00115 |
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Clone Names | 90713056 |
Gene ID | 1777 |
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Other Names | Deoxyribonuclease-2-alpha, Acid DNase, Deoxyribonuclease II alpha, DNase II alpha, Lysosomal DNase II, R31240_2, DNASE2, DNASE2A, DNL2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8894c was selected from the Center region of human DNASE2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DNASE2 |
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Synonyms | DNASE2A, DNL2 |
Function | Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation (PubMed:29259162, PubMed:31775019). Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells (PubMed:29259162). |
Cellular Location | Lysosome. |
Tissue Location | Expressed in monocytes/macrophages (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
DNASE2 is a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis.
References
Yasuda,T., et.al., J. Biol. Chem. 273 (5), 2610-2616 (1998)
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