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RASSF4 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H2L5
Clone Names 90713239
Additional Information
Other Names Ras association domain-containing protein 4, RASSF4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8942c was selected from the Center region of human RASSF4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RASSF4
Function Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.
Tissue Location Widely expressed. Frequently down-regulated in tumor cell lines. EMBL; AY216713; AAO61138.1; -; mRNA EMBL; AY216714; AAO61139.1; -; mRNA EMBL; AY216715; AAO61140.1; -; mRNA EMBL; AY216716; AAO61141.1; -; mRNA EMBL; AF260335; AAG44666.1; -; mRNA EMBL; AL353801; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC032593; AAH32593.1; -; mRNA EMBL; AL713716; CAD28511.1; -; mRNA CCDS; CCDS7208.1; -. [Q9H2L5-1] RefSeq; NP_114412.2; NM_032023.3. [Q9H2L5-1] BioGRID; 123820; 3 IntAct; Q9H2L5; 9 STRING; 9606.ENSP00000339692; - iPTMnet; Q9H2L5; - PhosphoSitePlus; Q9H2L5; - BioMuta; RASSF4; - DMDM; 109892952; - EPD; Q9H2L5; - jPOST; Q9H2L5; - MassIVE; Q9H2L5; - MaxQB; Q9H2L5; - PaxDb; Q9H2L5; - PeptideAtlas; Q9H2L5; - PRIDE; Q9H2L5; - ProteomicsDB; 80562; -. [Q9H2L5-1] ProteomicsDB; 80563; -. [Q9H2L5-2] ProteomicsDB; 80564; -. [Q9H2L5-3] ProteomicsDB; 80565; -. [Q9H2L5-4] Antibodypedia; 26967; 165 antibodies Ensembl; ENST00000340258; ENSP00000339692; ENSG00000107551. [Q9H2L5-1] GeneID; 83937; - KEGG; hsa:83937; - UCSC; uc001jbo.4; human. [Q9H2L5-1] CTD; 83937; - DisGeNET; 83937; - EuPathDB; HostDB:ENSG00000107551.20; - GeneCards; RASSF4; - HGNC; HGNC:20793; RASSF4 HPA; ENSG00000107551; Low tissue specificity MIM; 610559; gene neXtProt; NX_Q9H2L5; - OpenTargets; ENSG00000107551; - PharmGKB; PA134951366; - eggNOG; KOG4239; Eukaryota eggNOG; ENOG410Y2N1; LUCA GeneTree; ENSGT00940000160176; - HOGENOM; CLU_018893_1_0_1; - InParanoid; Q9H2L5; - KO; K09851; - OMA; IFIMEAD; - PhylomeDB; Q9H2L5; - TreeFam; TF319243; - BioGRID-ORCS; 83937; 6 hits in 790 CRISPR screens ChiTaRS; RASSF4; human GenomeRNAi; 83937; - Pharos; Q9H2L5; Tbio PRO; PR:Q9H2L5; - Proteomes; UP000005640; Chromosome 10 RNAct; Q9H2L5; protein Bgee; ENSG00000107551; Expressed in left lobe of thyroid gland and 202 other tissues ExpressionAtlas; Q9H2L5; baseline and differential Genevisible; Q9H2L5; HS GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW GO; GO:0007165; P:signal transduction; IEA:InterPro InterPro; IPR033614; C-RASSF InterPro; IPR000159; RA_dom InterPro; IPR033622; RASSF4 InterPro; IPR011524; SARAH_dom InterPro; IPR029071; Ubiquitin-like_domsf PANTHER; PTHR22738; PTHR22738; 1 PANTHER; PTHR22738:SF4; PTHR22738:SF4; 1 Pfam; PF16517; Nore1-SARAH; 1 Pfam; PF00788; RA; 1 SMART; SM00314; RA; 1 SUPFAM; SSF54236; SSF54236; 1 PROSITE; PS50200; RA; 1 PROSITE; PS50951; SARAH; 1 1: Evidence at protein level; Alternative splicing; Cell cycle; Phosphoprotein; Polymorphism; Reference proteome; Tumor suppressor CHAIN 1..321 /note="Ras association domain-containing protein 4" /id="PRO_0000240398" DOMAIN 174..262 /note="Ras-associating" /evidence="ECO:0000255|PROSITE-ProRule:PRU00166" DOMAIN 270..317 /note="SARAH" /evidence="ECO:0000255|PROSITE-ProRule:PRU00310" MOD_RES 141 /note="Phosphoserine" /evidence="ECO:0000250|UniProtKB:Q8CB96" VAR_SEQ 1..70 /note="Missing (in isoform 3)" /evidence="ECO:0000303|Ref.1" /id="VSP_019355" VAR_SEQ 29..46 /note="Missing (in isoform 2)" /evidence="ECO:0000303|Ref.1" /id="VSP_019356" VAR_SEQ 94 /note="L -> LGCWSLLLGLSSLSLPAAISALQLSVFR (in isoform 2)" /evidence="ECO:0000303|Ref.1" /id="VSP_019357" VAR_SEQ 95..126 /note="KEPSPQNGNITAQGPSIQPVHKAESSTDSSGP -> APGGGRGGPPADADQE RRQLHEPEEAQ (in isoform 4)" /evidence="ECO:0000303|Ref.1" /id="VSP_019358" VAR_SEQ 127..321 /note="Missing (in isoform 4)" /evidence="ECO:0000303|Ref.1" /id="VSP_019359" VARIANT 10 /note="H -> Y (in dbSNP:rs34692238)" /id="VAR_034438" VARIANT 88 /note="R -> G (in dbSNP:rs870957)" /id="VAR_034439" CONFLICT 107 /note="Q -> K (in Ref. 1; AAG44666 and 2; AAO61138)" /evidence="ECO:0000305" SEQUENCE 321 AA; 36748 MW; 8EB5990165886D99 CRC64; MKEDCLPSSH VPISDSKSIQ KSELLGLLKT YNCYHEGKSF QLRHREEEGT LIIEGLLNIA WGLRRPIRLQ MQDDREQVHL PSTSWMPRRP SCPLKEPSPQ NGNITAQGPS IQPVHKAESS TDSSGPLEEA EEAPQLMRTK SDASCMSQRR PKCRAPGEAQ RIRRHRFSIN GHFYNHKTSV FTPAYGSVTN VRVNSTMTTL QVLTLLLNKF RVEDGPSEFA LYIVHESGER TKLKDCEYPL ISRILHGPCE KIARIFLMEA DLGVEVPHEV AQYIKFEMPV LDSFVEKLKE EEEREIIKLT MKFQALRLTM LQRLEQLVEA K
Research Areas
Citations (0)

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Background

The function of RASSF4 has not yet been determined but it may involve a role in tumor suppression. RASSF4 may act as a KRAS effector protein and may promote apoptosis and cell cycle arrest. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described.

References

French,D., et.al., Blood 113 (19), 4512-4520 (2009)Grupe,A., et.al., Am. J. Hum. Genet. 78 (1), 78-88 (2006)

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$ 277.78
Cat# BP8942c
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