DAB1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O75553 |
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Clone Names | 90921073 |
Gene ID | 1600 |
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Other Names | Disabled homolog 1, DAB1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8986c was selected from the Center region of humanB1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DAB1 |
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Function | Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development. Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P97318}. |
Tissue Location | Mainly expressed in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DAB1 is adapter molecule functioning in neural development. It may regulate SIAH1 activity (By similarity).
References
Ranganathan S., et.al., J. Biol. Chem. 279:40536-40544(2004).
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