LY75 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O60449 |
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Clone Names | 91019066 |
Gene ID | 100526664;4065 |
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Other Names | Lymphocyte antigen 75, Ly-75, C-type lectin domain family 13 member B, DEC-205, gp200-MR6, CD205, LY75, CD205, CLEC13B |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8994c was selected from the Center region of human LY75. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | LY75 |
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Synonyms | CD205, CLEC13B |
Function | Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B- lymphocytes. |
Cellular Location | Membrane; Single-pass type I membrane protein |
Tissue Location | Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
LY75 acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. It causes reduced proliferation of B-lymphocytes.
References
Kato,M., et.al., Immunogenetics 47 (6), 442-450 (1998)McKay,P.F., et.al., Eur. J. Immunol. 28 (12), 4071-4083 (1998)
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