ADPRHL1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8NDY3 |
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Clone Names | 90819067 |
Gene ID | 113622 |
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Other Names | [Protein ADP-ribosylarginine] hydrolase-like protein 1, 32--, ADP-ribosylhydrolase 2, ADPRHL1, ARH2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9063a was selected from the N-term region of human ADPRHL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ADPRHL1 |
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Synonyms | ARH2 |
Function | Required for myofibril assembly and outgrowth of the cardiac chambers in the developing heart (By similarity). Appears to be catalytically inactive, showing no activity against O-acetyl-ADP-ribose (By similarity). |
Cellular Location | Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q6AZR2} |
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Provided below are standard protocols that you may find useful for product applications.
Background
ADPRHL1 is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction.
References
Dunham,A., et.al., Nature 428 (6982), 522-528 (2004)Glowacki,G., et.al., Protein Sci. 11 (7), 1657-1670 (2002)
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