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MTTP Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P55157 |
|---|---|
| Clone Names | 90723088 |
| Gene ID | 4547 |
|---|---|
| Other Names | Microsomal triglyceride transfer protein large subunit, MTTP, MTP |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9069b was selected from the C-term region of human MTTP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MTTP |
|---|---|
| Synonyms | MTP |
| Function | Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:16478722, PubMed:22236406, PubMed:23475612, PubMed:25108285, PubMed:26224785, PubMed:8876250, PubMed:8939939). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:16478722, PubMed:23475612, PubMed:26224785, PubMed:8876250, PubMed:8939939). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity). |
| Cellular Location | Endoplasmic reticulum. Golgi apparatus. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785) |
| Tissue Location | Liver and small intestine. Also found in ovary, testis and kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
MTTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a entral role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
References
Dai,K., et.al., Arterioscler. Thromb. Vasc. Biol. 30 (3), 568-574 (2010)Oliveira,C.P., et.al., J. Gastroenterol. Hepatol. 25 (2), 357-361 (2010)
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