|Other Names||Phosphate carrier protein, mitochondrial, Phosphate transport protein, PTP, Solute carrier family 25 member 3, SLC25A3, PHC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9080b was selected from the Center region of human SLC25A3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
SLC25A3 catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol.
Martins-de-Souza,D., et.al., BMC Psychiatry 9, 17 (2009)Mayr,J.A., et.al., Am. J. Hum. Genet. 80 (3), 478-484 (2007)
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