|Other Names||Voltage-dependent calcium channel gamma-7 subunit, Neuronal voltage-gated calcium channel gamma-7 subunit, Transmembrane AMPAR regulatory protein gamma-7, TARP gamma-7, CACNG7|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9136b was selected from the C-term region of human CACNG7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2 (PubMed:21172611).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in heart left ventricle (PubMed:21127204). Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The mouse protein stargazin is one of five subunits comprising neuronal voltage-gated calcium channels. It is thought to stabilize the calcium channel in an inactive (closed) state. Mutations in stargazin have been associated with absence seizures, also known as petit-mal or spike-wave seizures. CACNG7 is structurally similar to the mouse stargazin protein and is a member of the neuronal calcium channel gamma subunit protein family. It appears unlikely that CACNG7 is part of a functional calcium channel. Rather, it appears to inhibit the expression of a specific calcium channel subunit.
Wang Y., et.al., EMBO J. 25:5058-5070(2006).Moss F.J., et.al., EMBO J. 21:1514-1523(2002).
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