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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   CRNN Antibody (Center) Blocking Peptide   

CRNN Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UBG3
Clone Names 90909033
Additional Information
Gene ID 49860
Other Names Cornulin, 53 kDa putative calcium-binding protein, 53 kDa squamous epithelial-induced stress protein, 58 kDa heat shock protein, Squamous epithelial heat shock protein 53, Tumor-related protein, CRNN, C1orf10, DRC1, PDRC1, SEP53
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9147c was selected from the Center region of human CRNN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1 (PubMed:30009832). Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways (PubMed:30009832).
Cellular Location Cytoplasm. Note=Does not colocalize with TGM1
Tissue Location Expressed in the basal skin layer (at protein level) (PubMed:30009832). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR)
Research Areas
Citations (0)

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CRNN is a member of the fused gene family of proteins, which contain N terminus EF hand domains and multiple tandem peptide repeats. The encoded protein contains two EF hand Ca2+ binding domains in its N terminus and two glutamine and threonine rich 60 amino acid repeats in its C terminus.


Molina H.,, Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).Luthra M.G.,, Clin. Cancer Res. 13:912-919(2007).

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$ 277.78
Cat# BP9147c
Availability: 2 weeks
Bulk Size

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