|Other Names||Short-chain dehydrogenase/reductase 3, DD831, Retinal short-chain dehydrogenase/reductase 1, retSDR1, DHRS3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9188c was selected from the Center region of human DHRS3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the reduction of all-trans-retinal to all-trans- retinol in the presence of NADPH.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments|
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Provided below are standard protocols that you may find useful for product applications.
DHRS3 catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids.
Persson,B., et.al., Chem. Biol. Interact. 178 (1-3), 94-98 (2009)Roni,V., et.al., BMC Genomics 8, 42 (2007)
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