ATAD1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8NBU5 |
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Clone Names | 90819169 |
Gene ID | 84896 |
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Other Names | ATPase family AAA domain-containing protein 1, Thorase, ATAD1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9194b was selected from the C-term region of human ATAD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ATAD1 {ECO:0000303|PubMed:24843043, ECO:0000312|HGNC:HGNC:25903} |
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Function | Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24843043). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP- dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). |
Cellular Location | Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9D5T0}; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
References
Vasilescu,J., et.al., J. Proteome Res. 6 (1), 298-305 (2007)Olsen,J.V. et.al., Cell 127 (3), 635-648 (2006)
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