|Other Names||Regenerating islet-derived protein 3-alpha, REG-3-alpha, Hepatointestinal pancreatic protein, HIP/PAP, Human proislet peptide, Pancreatitis-associated protein 1, Regenerating islet-derived protein III-alpha, Reg III-alpha, Regenerating islet-derived protein 3-alpha 165 kDa form, Regenerating islet-derived protein 3-alpha 15 kDa form, REG3A, HIP, PAP, PAP1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9210a was selected from the N-term region of human REG3A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||HIP, PAP, PAP1|
|Function||Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.|
|Cellular Location||Secreted. Note=Found in the apical region of pancreatic acinar cells|
|Tissue Location||Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.|
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Provided below are standard protocols that you may find useful for product applications.
REG3A encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this protein is observed during pancreatic inflammation and liver carcinogenesis.
Medveczky,P., et.al., Biochem. J. 420 (2), 335-343 (2009)Scott,L.J., et.al, Proc. Natl. Acad. Sci. U.S.A. 106 (18), 7501-7506 (2009)Mukherjee,S., et.sl., J. Biol. Chem. 284 (8), 4881-4888 (2009)
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