|Other Names||Cytoplasmic dynein 1 intermediate chain 1, Cytoplasmic dynein intermediate chain 1, Dynein intermediate chain 1, cytosolic, DH IC-1, DYNC1I1, DNCI1, DNCIC1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9232b was selected from the C-term region of human DYNC1I1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.|
|Cellular Location||Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole|
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Provided below are standard protocols that you may find useful for product applications.
DYNC1I1 is the intermediate chains seem to help dynein bind to dynactin 150 kDa component. This protein may play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
Lam,C., et.al, J. Cell. Sci. 123 (PT 2), 202-212 (2010)Pfister,K.K., et.al, J. Cell Biol. 171 (3), 411-413 (2005)
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