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C20orf72 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BQP7 |
|---|---|
| Clone Names | 90826152 |
| Gene ID | 92667 |
|---|---|
| Other Names | Mitochondrial genome maintenance exonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03030}, 31-- {ECO:0000255|HAMAP-Rule:MF_03030}, MGME1 {ECO:0000255|HAMAP-Rule:MF_03030}, C20orf72, DDK1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9240c was selected from the Center region of human C20orf72. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MGME1 {ECO:0000255|HAMAP-Rule:MF_03030} |
|---|---|
| Synonyms | C20orf72, DDK1 |
| Function | Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5- hydroxymethylcytosine (5hmC)-containing DNA in stem cells. |
| Cellular Location | Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03030, ECO:0000269|PubMed:23313956, ECO:0000269|PubMed:23358826} |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Deloukas,P., et.al, Nature 414 (6866), 865-871 (2001)
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$ 277.78
Cat# BP9240c
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