|Other Names||Transmembrane and TPR repeat-containing protein 2, TMTC2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9252b was selected from the C-term region of human TMTC2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3.|
|Cellular Location||Membrane; Multi-pass membrane protein. Endoplasmic reticulum|
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Provided below are standard protocols that you may find useful for product applications.
Nakano,M., et.al, Proc. Natl. Acad. Sci. U.S.A. 106 (31), 12838-12842 (2009)Mole,D.R., et.al, J. Biol. Chem. 284 (25), 16767-16775 (2009)
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