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KCTD12 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96CX2
Clone Names 90723068
Additional Information
Other Names BTB/POZ domain-containing protein KCTD12, Pfetin, Predominantly fetal expressed T1 domain, KCTD12, C13orf2, KIAA1778, PFET1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9273c was selected from the Center region of human KCTD12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCTD12
Synonyms C13orf2, KIAA1778, PFET1
Function Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
Cellular Location Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane
Tissue Location Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung. EMBL; AF359381; AAQ15187.1; -; mRNA EMBL; BC013764; AAH13764.1; -; mRNA CCDS; CCDS9455.1; - RefSeq; NP_612453.1; NM_138444.3 PDB; 6M8S; X-ray; 3.71 A; A/B/M/O/P=200-325 PDB; 6QZL; X-ray; 1.98 A; A/B/C/D/E=202-325 PDBsum; 6M8S; - PDBsum; 6QZL; - SMR; Q96CX2; - BioGRID; 125419; 74 CORUM; Q96CX2; - IntAct; Q96CX2; 16 MINT; Q96CX2; - STRING; 9606.ENSP00000366694; - GuidetoPHARMACOLOGY; 1918; - iPTMnet; Q96CX2; - MetOSite; Q96CX2; - PhosphoSitePlus; Q96CX2; - BioMuta; KCTD12; - DMDM; 50401124; - REPRODUCTION-2DPAGE; IPI00060715; - EPD; Q96CX2; - jPOST; Q96CX2; - MassIVE; Q96CX2; - MaxQB; Q96CX2; - PaxDb; Q96CX2; - PeptideAtlas; Q96CX2; - PRIDE; Q96CX2; - ProteomicsDB; 76237; - Antibodypedia; 42369; 136 antibodies Ensembl; ENST00000377474; ENSP00000366694; ENSG00000178695 GeneID; 115207; - KEGG; hsa:115207; - UCSC; uc010aeu.2; human CTD; 115207; - DisGeNET; 115207; - EuPathDB; HostDB:ENSG00000178695.5; - GeneCards; KCTD12; - HGNC; HGNC:14678; KCTD12 HPA; ENSG00000178695; Low tissue specificity MIM; 610521; gene neXtProt; NX_Q96CX2; - OpenTargets; ENSG00000178695; - PharmGKB; PA25512; - eggNOG; KOG2723; Eukaryota eggNOG; ENOG410Z155; LUCA GeneTree; ENSGT00940000161074; - HOGENOM; CLU_057051_0_1_1; - InParanoid; Q96CX2; - KO; K21918; - OMA; DHGMSDR; - OrthoDB; 1579292at2759; - PhylomeDB; Q96CX2; - TreeFam; TF315332; - BioGRID-ORCS; 115207; 3 hits in 786 CRISPR screens ChiTaRS; KCTD12; human GeneWiki; KCTD12; - GenomeRNAi; 115207; - Pharos; Q96CX2; Tbio PRO; PR:Q96CX2; - Proteomes; UP000005640; Chromosome 13 RNAct; Q96CX2; protein Bgee; ENSG00000178695; Expressed in upper lobe of lung and 244 other tissues ExpressionAtlas; Q96CX2; baseline and differential Genevisible; Q96CX2; HS GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell GO; GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell GO; GO:0042802; F:identical protein binding; IPI:IntAct GO; GO:0003723; F:RNA binding; HDA:UniProtKB GO; GO:0051260; P:protein homooligomerization; IEA:InterPro InterPro; IPR000210; BTB/POZ_dom InterPro; IPR011333; SKP1/BTB/POZ_sf InterPro; IPR003131; T1-type_BTB Pfam; PF02214; BTB_2; 1 SMART; SM00225; BTB; 1 SUPFAM; SSF54695; SSF54695; 1 1: Evidence at protein level; 3D-structure; Acetylation; Cell junction; Cell membrane; Cell projection; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse INIT_MET 1 /note="Removed" /evidence="ECO:0000244|PubMed:22814378" CHAIN 2..325 /note="BTB/POZ domain-containing protein KCTD12" /id="PRO_0000191295" MOD_RES 2 /note="N-acetylalanine" /evidence="ECO:0000244|PubMed:22814378" MOD_RES 119 /note="Phosphotyrosine" /evidence="ECO:0000250|UniProtKB:Q6WVG3" MOD_RES 151 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:24275569" MOD_RES 171 /note="Phosphoserine" /evidence="ECO:0000250|UniProtKB:Q6WVG3" MOD_RES 185 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:18669648" MOD_RES 196 /note="Phosphothreonine" /evidence="ECO:0000250|UniProtKB:Q6WVG3" MOD_RES 200 /note="Phosphoserine" /evidence="ECO:0000250|UniProtKB:Q6WVG3" STRAND 208..219 /evidence="ECO:0000244|PDB:6QZL" STRAND 236..241 /evidence="ECO:0000244|PDB:6QZL" HELIX 242..249 /evidence="ECO:0000244|PDB:6QZL" HELIX 250..252 /evidence="ECO:0000244|PDB:6QZL" STRAND 265..273 /evidence="ECO:0000244|PDB:6QZL" HELIX 277..286 /evidence="ECO:0000244|PDB:6QZL" STRAND 290..301 /evidence="ECO:0000244|PDB:6QZL" STRAND 313..324 /evidence="ECO:0000244|PDB:6QZL" SEQUENCE 325 AA; 35701 MW; 6254CC18E27275A9 CRC64; MALADSTRGL PNGGGGGGGS GSSSSSAEPP LFPDIVELNV GGQVYVTRRC TVVSVPDSLL WRMFTQQQPQ ELARDSKGRF FLDRDGFLFR YILDYLRDLQ LVLPDYFPER SRLQREAEYF ELPELVRRLG APQQPGPGPP PSRRGVHKEG SLGDELLPLG YSEPEQQEGA SAGAPSPTLE LASRSPSGGA AGPLLTPSQS LDGSRRSGYI TIGYRGSYTI GRDAQADAKF RRVARITVCG KTSLAKEVFG DTLNESRDPD RPPERYTSRY YLKFNFLEQA FDKLSESGFH MVACSSTGTC AFASSTDQSE DKIWTSYTEY VFCRE
Research Areas
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Drenos,F.,, Hum. Mol. Genet. 18 (12), 2305-2316 (2009)Suehara,Y.,, Clin. Cancer Res. 14 (6), 1707-1717 (2008)Cauchi,S.,, J. Mol. Med. 86 (3), 341-348 (2008)

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$ 277.78
Cat# BP9273c
Availability: 2 weeks
Bulk Size

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