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SELT Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P62341
Clone Names 91109278
Additional Information
Gene ID 51714
Other Names Selenoprotein T, SelT, SELT
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9306a was selected from the N-term region of human SELT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SELENOT {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:18136}
Function Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP- induced insulin secretion (By similarity).
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q1H5H1}; Single-pass membrane protein
Tissue Location Ubiquitous. Highly expressed in the endocrine pancreas.
Research Areas
Citations (0)

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Background

SELT encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

References

Kryukov,G.V., et.al., Science 300 (5624), 1439-1443 (2003)Kryukov,G.V., et.al., J. Biol. Chem. 274 (48), 33888-33897 (1999)

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$ 277.78
Cat# BP9306a
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Availability: 2 weeks
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