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WDR46 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O15213
Additional Information
Other Names WD repeat-containing protein 46, WD repeat-containing protein BING4, WDR46, BING4, C6orf11
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name WDR46
Synonyms BING4, C6orf11
Function Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.
Cellular Location Nucleus, nucleolus. EMBL; AF447870; AAQ04645.1; -; mRNA EMBL; AL662820; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL662827; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL844527; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BX000343; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; Z97184; CAB09994.2; -; Genomic_DNA EMBL; AL031228; CAB09994.2; JOINED; Genomic_DNA EMBL; BC000388; AAH00388.1; -; mRNA CCDS; CCDS4772.1; - RefSeq; NP_001157739.1; NM_001164267.1 RefSeq; NP_005443.3; NM_005452.5 BioGRID; 114694; 115 IntAct; O15213; 8 MINT; O15213; - STRING; 9606.ENSP00000363746; - iPTMnet; O15213; - PhosphoSitePlus; O15213; - SwissPalm; O15213; - BioMuta; WDR46; - EPD; O15213; - jPOST; O15213; - MassIVE; O15213; - MaxQB; O15213; - PaxDb; O15213; - PeptideAtlas; O15213; - PRIDE; O15213; - ProteomicsDB; 48513; - Antibodypedia; 29045; 52 antibodies DNASU; 9277; - Ensembl; ENST00000374617; ENSP00000363746; ENSG00000227057 Ensembl; ENST00000383208; ENSP00000372695; ENSG00000206284 Ensembl; ENST00000432609; ENSP00000402869; ENSG00000236222 Ensembl; ENST00000432933; ENSP00000399454; ENSG00000204221 Ensembl; ENST00000457382; ENSP00000405614; ENSG00000226916 GeneID; 9277; - KEGG; hsa:9277; - UCSC; uc003ods.4; human CTD; 9277; - DisGeNET; 9277; - EuPathDB; HostDB:ENSG00000227057.7; - GeneCards; WDR46; - HGNC; HGNC:13923; WDR46 HPA; ENSG00000227057; Low tissue specificity MIM; 611440; gene neXtProt; NX_O15213; - OpenTargets; ENSG00000227057; - PharmGKB; PA25924; - eggNOG; KOG1272; Eukaryota eggNOG; ENOG410XP5D; LUCA GeneTree; ENSGT00390000007075; - HOGENOM; CLU_022996_2_0_1; - InParanoid; O15213; - KO; K14768; - OMA; KYTFIYD; - OrthoDB; 430457at2759; - PhylomeDB; O15213; - TreeFam; TF300861; - Reactome; R-HSA-6790901; rRNA modification in the nucleus and cytosol Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol SignaLink; O15213; - BioGRID-ORCS; 9277; 531 hits in 790 CRISPR screens ChiTaRS; WDR46; human GeneWiki; WDR46; - GenomeRNAi; 9277; - Pharos; O15213; Tdark PRO; PR:O15213; - Proteomes; UP000005640; Chromosome 6 RNAct; O15213; protein Bgee; ENSG00000227057; Expressed in adenohypophysis and 202 other tissues ExpressionAtlas; O15213; baseline and differential Genevisible; O15213; HS GO; GO:0005730; C:nucleolus; IBA:GO_Central GO; GO:0005654; C:nucleoplasm; TAS:Reactome GO; GO:0032040; C:small-subunit processome; IBA:GO_Central GO; GO:0003723; F:RNA binding; HDA:UniProtKB GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central GO; GO:0006364; P:rRNA processing; TAS:Reactome Gene3D;; -; 1 InterPro; IPR012952; BING4_C_dom InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf InterPro; IPR001680; WD40_repeat InterPro; IPR017986; WD40_repeat_dom InterPro; IPR036322; WD40_repeat_dom_sf InterPro; IPR040315; WDR46/Utp7 PANTHER; PTHR14085; PTHR14085; 1 Pfam; PF08149; BING4CT; 1 SMART; SM01033; BING4CT; 1 SMART; SM00320; WD40; 4 SUPFAM; SSF50978; SSF50978; 1 PROSITE; PS50082; WD_REPEATS_2; 1 PROSITE; PS50294; WD_REPEATS_REGION; 1 1: Evidence at protein level; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; WD repeat CHAIN 1..610 /note="WD repeat-containing protein 46" /id="PRO_0000051395" REPEAT 193..234 /note="WD 1" REPEAT 235..272 /note="WD 2" REPEAT 274..312 /note="WD 3" REPEAT 315..354 /note="WD 4" REPEAT 357..396 /note="WD 5" REPEAT 399..436 /note="WD 6" MOD_RES 41 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:18220336, ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569" VARIANT 94 /note="T -> A (in dbSNP:rs3130257)" /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:15498874, ECO:0000269|PubMed:9545376" /id="VAR_053433" VARIANT 124 /note="S -> Y (in dbSNP:rs34704405)" /id="VAR_053434" VARIANT 341 /note="V -> A (in dbSNP:rs14398)" /evidence="ECO:0000269|PubMed:14574404" /id="VAR_022025" SEQUENCE 610 AA; 68071 MW; 0C11DA8ED92CA39E CRC64; METAPKPGKD VPPKKDKLQT KRKKPRRYWE EETVPTTAGA SPGPPRNKKN RELRPQRPKN AYILKKSRIS KKPQVPKKPR EWKNPESQRG LSGTQDPFPG PAPVPVEVVQ KFCRIDKSRK LPHSKAKTRS RLEVAEAEEE ETSIKAARSE LLLAEEPGFL EGEDGEDTAK ICQADIVEAV DIASAAKHFD LNLRQFGPYR LNYSRTGRHL AFGGRRGHVA ALDWVTKKLM CEINVMEAVR DIRFLHSEAL LAVAQNRWLH IYDNQGIELH CIRRCDRVTR LEFLPFHFLL ATASETGFLT YLDVSVGKIV AALNARAGRL DVMSQNPYNA VIHLGHSNGT VSLWSPAMKE PLAKILCHRG GVRAVAVDST GTYMATSGLD HQLKIFDLRG TYQPLSTRTL PHGAGHLAFS QRGLLVAGMG DVVNIWAGQG KASPPSLEQP YLTHRLSGPV HGLQFCPFED VLGVGHTGGI TSMLVPGAGE PNFDGLESNP YRSRKQRQEW EVKALLEKVP AELICLDPRA LAEVDVISLE QGKKEQIERL GYDPQAKAPF QPKPKQKGRS STASLVKRKR KVMDEEHRDK VRQSLQQQHH KEAKAKPTGA RPSALDRFVR
Research Areas
Citations (0)

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WDR46 contains 6 WD repeats.


Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)Andersen, J.S., et al. Curr. Biol. 12(1):1-11(2002)

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$ 277.78
Cat# BP9418a
Availability: 2 weeks
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