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LRC17 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8N6Y2
Additional Information
Other Names Leucine-rich repeat-containing protein 17, p37NB, LRRC17, P37NB
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRRC17
Synonyms P37NB
Function Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity).
Cellular Location Secreted, extracellular space.
Tissue Location Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells. EMBL; U32907; AAB41565.1; -; mRNA EMBL; AY358889; AAQ89248.1; -; mRNA EMBL; AC073127; AAS07483.1; -; Genomic_DNA EMBL; BC027903; AAH27903.1; -; mRNA CCDS; CCDS34721.1; -. [Q8N6Y2-1] CCDS; CCDS5727.1; -. [Q8N6Y2-2] PIR; G02020; G02020 RefSeq; NP_001026862.1; NM_001031692.2. [Q8N6Y2-1] RefSeq; NP_005815.2; NM_005824.2. [Q8N6Y2-2] RefSeq; XP_005250165.1; XM_005250108.1. [Q8N6Y2-1] STRING; 9606.ENSP00000344242; - iPTMnet; Q8N6Y2; - PhosphoSitePlus; Q8N6Y2; - BioMuta; LRRC17; - DMDM; 51701682; - jPOST; Q8N6Y2; - MassIVE; Q8N6Y2; - MaxQB; Q8N6Y2; - PaxDb; Q8N6Y2; - PeptideAtlas; Q8N6Y2; - PRIDE; Q8N6Y2; - ProteomicsDB; 72249; -. [Q8N6Y2-1] ProteomicsDB; 72250; -. [Q8N6Y2-2] Antibodypedia; 31152; 51 antibodies DNASU; 10234; - Ensembl; ENST00000249377; ENSP00000249377; ENSG00000128606. [Q8N6Y2-2] Ensembl; ENST00000339431; ENSP00000344242; ENSG00000128606. [Q8N6Y2-1] GeneID; 10234; - KEGG; hsa:10234; - UCSC; uc003vat.4; human. [Q8N6Y2-1] CTD; 10234; - DisGeNET; 10234; - EuPathDB; HostDB:ENSG00000128606.12; - GeneCards; LRRC17; - HGNC; HGNC:16895; LRRC17 HPA; ENSG00000128606; Tissue enhanced (ovary) MIM; 618749; gene neXtProt; NX_Q8N6Y2; - OpenTargets; ENSG00000128606; - PharmGKB; PA134866295; - eggNOG; KOG0619; Eukaryota eggNOG; COG4886; LUCA GeneTree; ENSGT00940000156400; - HOGENOM; CLU_049990_0_0_1; - InParanoid; Q8N6Y2; - OMA; WICDYNI; - OrthoDB; 282791at2759; - PhylomeDB; Q8N6Y2; - BioGRID-ORCS; 10234; 6 hits in 782 CRISPR screens ChiTaRS; LRRC17; human GeneWiki; LRRC17; - GenomeRNAi; 10234; - Pharos; Q8N6Y2; Tdark PRO; PR:Q8N6Y2; - Proteomes; UP000005640; Chromosome 7 RNAct; Q8N6Y2; protein Bgee; ENSG00000128606; Expressed in secondary oocyte and 199 other tissues ExpressionAtlas; Q8N6Y2; baseline and differential Genevisible; Q8N6Y2; HS GO; GO:0031012; C:extracellular matrix; IBA:GO_Central GO; GO:0005615; C:extracellular space; ISS:UniProtKB GO; GO:0048539; P:bone marrow development; ISS:UniProtKB GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB GO; GO:0001503; P:ossification; IEA:UniProtKB-KW Gene3D; 3.80.10.10; -; 2 InterPro; IPR000483; Cys-rich_flank_reg_C InterPro; IPR001611; Leu-rich_rpt InterPro; IPR003591; Leu-rich_rpt_typical-subtyp InterPro; IPR032675; LRR_dom_sf Pfam; PF13855; LRR_8; 2 SMART; SM00369; LRR_TYP; 6 SMART; SM00082; LRRCT; 2 PROSITE; PS51450; LRR; 6 2: Evidence at transcript level; Alternative splicing; Leucine-rich repeat; Osteogenesis; Polymorphism; Reference proteome; Repeat; Secreted; Signal SIGNAL 1..18 /evidence="ECO:0000255" CHAIN 19..441 /note="Leucine-rich repeat-containing protein 17" /id="PRO_0000021608" REPEAT 82..103 /note="LRR 1" REPEAT 106..127 /note="LRR 2" REPEAT 130..151 /note="LRR 3" DOMAIN 163..214 /note="LRRCT 1" DOMAIN 225..268 /note="LRRNT" REPEAT 269..290 /note="LRR 4" REPEAT 293..314 /note="LRR 5" REPEAT 317..340 /note="LRR 6" DOMAIN 350..402 /note="LRRCT 2" VAR_SEQ 310..313 /note="AAFL -> GSLR (in isoform 2)" /evidence="ECO:0000303|PubMed:8982252" /id="VSP_011424" VAR_SEQ 314..441 /note="Missing (in isoform 2)" /evidence="ECO:0000303|PubMed:8982252" /id="VSP_011425" VARIANT 95 /note="T -> I (in dbSNP:rs34613342)" /id="VAR_051103" VARIANT 119 /note="K -> E (in dbSNP:rs3800939)" /id="VAR_051104" VARIANT 187 /note="G -> A (in dbSNP:rs1057066)" /evidence="ECO:0000269|PubMed:8982252" /id="VAR_051105" CONFLICT 214 /note="Missing (in Ref. 2; AAQ89248)" /evidence="ECO:0000305" SEQUENCE 441 AA; 51800 MW; F629666C807A4254 CRC64; MRVVTIVILL CFCKAAELRK ASPGSVRSRV NHGRAGGGRR GSNPVKRYAP GLPCDVYTYL HEKYLDCQER KLVYVLPGWP QDLLHMLLAR NKIRTLKNNM FSKFKKLKSL DLQQNEISKI ESEAFFGLNK LTTLLLQHNQ IKVLTEEVFI YTPLLSYLRL YDNPWHCTCE IETLISMLQI PRNRNLGNYA KCESPQEQKN KKLRQIKSEQ LCNEEEKEQL DPKPQVSGRP PVIKPEVDST FCHNYVFPIQ TLDCKRKELK KVPNNIPPDI VKLDLSYNKI NQLRPKEFED VHELKKLNLS SNGIEFIDPA AFLGLTHLEE LDLSNNSLQN FDYGVLEDLY FLKLLWLRDN PWRCDYNIHY LYYWLKHHYN VHFNGLECKT PEEYKGWSVG KYIRSYYEEC PKDKLPAYPE SFDQDTEDDE WEKKHRDHTA KKQSVIITIV G
Research Areas
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Background

LRC17 involved in bone homeostasis. This protein acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors

References

Kim, T., et al. J. Biol. Chem. 284(22):15308-15316(2009)Kim, D., et al. Biochim. Biophys. Acta 1309(3):183-188(1996)

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$ 277.78
Cat# BP9419b
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