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HNF4A Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P41235
Additional Information
Gene ID 3172
Other Names Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4, HNF4A, HNF4, NR2A1, TCF14
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNF4A
Synonyms HNF4, NR2A1, TCF14
Function Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698).
Cellular Location Nucleus.
Research Areas
Citations (0)
citation

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Background

HNF4A is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines.

References

Koh, W., et al. BMC Genomics 11 SUPPL 1, S6 (2010) Wang, F., et al. Chin. Med. J. 122(20):2477-2482(2009)Taghavi, S.M., et al. Cardiovasc Diabetol 8, 63 (2009) Guo, H., et al. Biochem. J. 394 (PT 2), 379-387 (2006) Hong, Y.H., et al. J. Biol. Chem. 278(30):27495-27501(2003)

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$ 277.78
Cat# BP9435a
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