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GFRA1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P56159
Additional Information
Gene ID 2674
Other Names GDNF family receptor alpha-1, GDNF receptor alpha-1, GDNFR-alpha-1, GFR-alpha-1, RET ligand 1, TGF-beta-related neurotrophic factor receptor 1, GFRA1, GDNFRA, RETL1, TRNR1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GFRA1
Synonyms GDNFRA, RETL1, TRNR1
Function Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q62997}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q62997}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q62997}. Endosome {ECO:0000250|UniProtKB:Q62997}. Endosome, multivesicular body {ECO:0000250|UniProtKB:Q62997}. Note=Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies {ECO:0000250|UniProtKB:Q62997}
Research Areas
Citations (0)

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Background

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor.

References

??ouza, R.P., et al. J Psychiatr Res (2010) In press :??im, M.H., et al. Mol. Cell. Biol. 29(8):2264-2277(2009)??ini Prato, A., et al. Medicine (Baltimore) 88(2):83-90(2009)??arkash, V., et al. J. Biol. Chem. 283(50):35164-35172(2008)??ing, Z., et al. Am. J. Clin. Pathol. 130(6):892-896(2008)

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$ 277.78
Cat# BP9468c
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