|Other Names||Protein EMSY, EMSY, C11orf30|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338).|
|Cellular Location||Nucleus. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process|
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Provided below are standard protocols that you may find useful for product applications.
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2.
??sparza-Gordillo, J., et al. Nat. Genet. 41(5):596-601(2009)??arapaty, S., et al. J. Biol. Chem. 284(12):7542-7552(2009)??avaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)??ega, A., et al. Gynecol. Oncol. 112(1):210-214(2009)
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